SFB 1032: Nanoagents for Spatiotemporal Control of Molecular and Cellular Reactions

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Enhancing molecular interactions using DNA and RNA na-noscaffolds

DNA nanostructures can be used to arrange molecules precisely into specific geometries and thus control their interactions which each other. We will utilize this capability to enhance reactions be-tween DNA and RNA molecules with strong secondary structures, which can be used for molecular amplification and sensor applications. Nucleic acid nanostructures will further be used as scaffolds for the realization of synthetic multienzyme systems. In addition to conventional DNA origami struc-tures, we will utilize dendrimeric structures and also RNA-based scaffolds, which can be produced by transcription in vitro or even in vivo.