SFB 1032: Nanoagents for Spatiotemporal Control of Molecular and Cellular Reactions

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Surface designs for the control of cell migration

We investigate the migration of single cells as well as small countable ensembles of cells in purpose-designed geometries of chemically modified surfaces using time-lapse microscopy and automated image analysis. The cell assays yield multiple phenomenological parameters for discrimination of cancer cell lines, assessment of drug’s efficacy and comparison of quantitative observables of collective cell behavior with simulations. Spatio-temporal activity during cell polarization, lamellipodia formation and directed migration is imaged using fluorescent Rho-GTPases, photoswitchable inhibitors and nanoagents furnished with ephrins in combination with micro-patterns.