SFB 1032: Nanoagents for Spatiotemporal Control of Molecular and Cellular Reactions

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Nucleic acid nanoagents utilizing the intracellular microRNA machinery for switching functions in cells

Tissue-specific expression of micro RNA (miR) genes and the mechanism of RNA interference (RNAi) control the expression of our genome. We will exploit recent knowledge on miR function in tumors for the therapeutic delivery of nanoagents to stop tumor growth and chemoresistance. Adap-tor based nucleic acid constructs, sequence-defined oligo amino amides, and mesoporous silica nanoparticles will be developed to serve for intracellular delivery of miR sensors and RNAi nanoagents for the therapeutic or biological modulation of cell functions.