SFB 1032: Nanoagents for Spatiotemporal Control of Molecular and Cellular Reactions

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Switchable Mesoporous Nanoconstructs for Controlling Cell Functions in Space and Time

The goal of this collaborative project is to control cell functions in space and time by means of novel nanoagents based on multifunctional porous nanoparticles. During the next project period we will extend the scope of sensing and release functionalities implemented in the spatially segmented po-rous nanoagents. For instance, nanoagents containing microRNA sensing release triggers will be used for the controlled cytosolic delivery and release of bioactive oligonucleotides in tumor cells. Moreover, we will design 2D nanoagent arrays for controlling cell migration, for example through contact inhibition of locomotion (CIL) agents.